How to Use de novo in a Sentence

de novo

adverb or adjective
  • Couch asked for a trial de novo, which is a new trial on the entire case.
    — Ko Lyn Cheang, The Indianapolis Star, 5 Apr. 2023
  • Known as de novo, it can be used to bring novel, low-risk medical devices to market.
    — Rachana Pradhan, CNN, 26 Nov. 2021
  • In fact, with every decade of life, the number of de novo mutations in sperm doubles.
    — Alice Park, Time, 23 Dec. 2019
  • Yet, in a strict sense, nothing in evolution is created de novo.
    — Quanta Magazine, 9 Apr. 2020
  • The next step is to better understand how de novo mutations function over time.
    — Alice Park, Time, 23 Dec. 2019
  • Some early efforts to use deep learning for de novo protein design have not made use of large language models.
    — Rob Toews, Forbes, 16 July 2023
  • The study from the other team is in press, but found neither inherited nor de novo variants linked to autism in the regions.
    — Nicholette Zeliadt, Scientific American, 19 Apr. 2018
  • That confirmed that the de novo mutations were indeed playing some role in contributing to autism.
    — Alice Park, Time, 23 Dec. 2019
  • The last de novo to open in the Houston area was Mint National Bank.
    — Andrea Leinfelder, Houston Chronicle, 30 Sep. 2019
  • Most of these genes lead to autism primarily through de novo variants — variants that are new in the person and not present in their parents.
    — Pamela Feliciano, STAT, 22 Aug. 2022
  • If not, what are these giants doing to make that de novo certificate meaningful at the top of the hiring funnel?
    — Ryan Craig, Forbes, 11 June 2021
  • Instead, by applying de novo, the NFL had a lower bar to meet.
    — Michael McCann, SI.com, 12 Oct. 2017
  • Greg really was a large part of the reason why Goat was created, but this was his first de novo deal, was Ring.
    — Recode Staff, Recode, 20 Apr. 2018
  • Rivers was diagnosed de novo, which meant the breast cancer had already spread to other parts of her body at the time of diagnosis.
    — Sierra Leone Starks, Allure, 9 Dec. 2022
  • What that does is provides more sequence diversity and eliminates bias in de novo designs.
    — John Cumbers, Forbes, 10 Jan. 2023
  • Sometimes this means applying for a de novo license, sometimes this is an acquisition.
    — Steven Ehrlich, Forbes, 30 Aug. 2021
  • This is not relevant for de novo mutation, where the frequency is very low by definition.
    — Razib Khan, Discover Magazine, 21 Oct. 2012
  • But some scientists say that de novo protein design will lead to medicines that can’t be made from optimizing existing proteins.
    — Ryan Cross, BostonGlobe.com, 3 Nov. 2022
  • Rosetta contained a precise model of the spike; Cao had written scripts that used that model to generate, de novo, binders that might work.
    — Matthew Hutson, The New Yorker, 18 Sep. 2020
  • Many of them may also be de novo, and part of the reason why paternal age is so important in predicting these tendencies in offspring.
    — Razib Khan, Discover Magazine, 24 Jan. 2013
  • For Baker, de novo design represents the summit of his quarter-century quest.
    — Jonathon Keats, Discover Magazine, 30 Oct. 2018
  • Without the freedom of de novo protein design, Baker’s Death Star would never have gotten off the ground.
    — Jonathon Keats, Discover Magazine, 30 Oct. 2018
  • The girls’ specific gene mutation — known as de novo SPG4 — is extremely rare.
    — Dana Hedgpeth, Washington Post, 19 Mar. 2023
  • Later, at a big hospital in Columbus, an oncologist diagnosed me with metastatic breast cancer de novo.
    — Tori Geib As Told To Zee Krstic, Good Housekeeping, 16 Dec. 2020
  • Absci and Helixon are also working with drugmakers to design medicines for cancer and autoimmune diseases using de novo methods.
    — Karen Hao, WSJ, 7 Dec. 2022
  • Unfortunately, deciphering the function of de novo genes is far more difficult than identifying them.
    — Quanta Magazine, 18 Aug. 2015
  • Protein researchers and entrepreneurs seem even more excited about AlphaFold’s potential to boost the burgeoning field of de novo protein design.
    — Rob Toews, Forbes, 3 Oct. 2021
  • Khan first started working on Haven’s application for a de novo (new) federal credit union banking charter back in 2023.
    — Jeff Kauflin, Forbes.com, 21 Jan. 2026
  • At this moment, the helpful types of de novo proteins are attracting an increasing amount of scientific energy and expertise, and the molecules may be coming to a clinic near you.
    — Rowan Jacobsen, Scientific American, 27 June 2021
  • The company says the results are significant and under review by the FDA for possible de novo pre-market approval.
    — Stat Staff, STAT, 20 Sep. 2021

Some of these examples are programmatically compiled from various online sources to illustrate current usage of the word 'de novo.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

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